Innovative, Award-WinningLC-MS Platform

Innovative, Award-WinningLC-MS Platform

Newomics is on a mission to enable precision medicine with tools and applications. Our new DuoESI system is an integrated front-end solution for superior microflow and nanoflow LCMS.

High Sensitivity

Robustness

Throughput

The NewomicsPlatform

DuoESI

Source

MEA

Chip

M3

Emitter

Unify Your Workflow

Our DuoESI Platform


The DuoESI platform is the first fully integrated front-end solution for superior microflow and nanoflow LC-MS. A nanoflow module for the MEA chip and a microflow module for the M3 emitter are included with the platform.

The DuoESI source is compatible with all mass spectrometers from Agilent, Bruker, and Thermo Fisher.

Go Beyond the Column

Our MEA Chip


Our proprietary MEA chip achieves performance in small-volume bottom-up proteomics on a par with the top commercial columns. All this while introducing novel functionalities that are not feasible with current nanoflow LC column technologies.

It expands the capabilities of LC-MS and opens the door to new and exciting advancements in proteomics.

M3 Emitter Newomics

Enable New Applications

Our M3 Emitter


Our award-winning multinozzle M3 Emitter splits incoming flow into multiple smaller streams, dramatically enhancing ionization for microflow LC-MS. Our MEA chip monolithically integrates the M3 Emitter with an on-chip LC column, reducing dead volume and simplifying the connection for nanoflow LC-MS.

It enables new mass spectrometry applications for clinical diagnostics, biomarker discovery, drug development, food and environmental monitoring, forensic analysis, and more.

Enhanced LC-MS Performance

Sensitivity

5 - 50x

more sensitive compared to conventional methods.

Robustness

CV ≤ 5%

from 300 plasma injections.

Throughput

< 1 min.

per sample. More than 60 samples per hour.

See How Our M3 Emitters Work


Testimonials


Compared to the conventional single-nozzle emitters, the M3 emitter from Newomics provides 3-5 times higher peptide signals in ESI-MS and more robust and stable spray across the LC gradient. This allows me to use microliter flow rate LC-MS for a large set of biological samples for biomarker discovery, and ensures the reproducible results and similar sensitivity as nanoLC-MS has.

Shujia Dai, Ph.D.
Sanofi

The 8-nozzle emitter showed a 5-10-fold increase in sensitivity for protein therapeutics in human serum compared to the standard LC-MS (HESI source) at the flow rate of 5 μL/min. Preliminary analysis of replicate injections from the same samples showed an excellent CV by the measurement of peak area ratios and no additional carryover.

Ji Ma, Ph.D.
formerly with Amgen

3X improvement in peak intensities was observed for the 8-nozzle emitter in comparison with the ESI sprayer for non-denaturing LC-MS. Moreover, the generally sharper peaks and charge envelope shifted towards higher m/z suggest a more nanospray-like emission and possibly better preservation of the native conformation.

Theresa McLaughlin, Ph.D.
Stanford

From my tests, the detection of a mix of 10 peptides spiked in plasma extracts, was 5-6X more sensitive (and up to > 10X) with Newomics multi-nozzle emitter than with classical ESI source with a single-nozzle.

Bertrand Rochat, Ph.D.
University of Lausanne

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