MEA Chip
Our silicon-based, plug-and-play, nanoflow MEA chip integrates an LC column, an ESI emitter, and a post-column inlet (PCI) for enhanced results in sensitivity, reproducibility, and robustness. This allows them to be used for most mainstream proteomic studies while providing a platform for novel experiments.
Our silicon-based, plug-and-play, nanoflow MEA chip integrates an LC column, an ESI emitter, and a post-column inlet (PCI) for enhanced results in sensitivity, reproducibility, and robustness. This allows them to be used for most mainstream proteomic studies while providing a platform for novel experiments.
Flexible Configurations
Find the Perfect Fit For Your Project
C1001
70 µm id, 15 cm L, 1.5 µm
C18 beads, 1-nozzle, 10 µm
C1002
70 µm id, 20 cm L, 1.5 µm
C18 beads, 1-nozzle, 10 µm
C1005
70 µm id, 15 cm L, 1.9 µm
C18 beads, 1-nozzle, 10 µm
C1006
70 µm id, 20 cm L, 1.9 µm
C18 beads, 1-nozzle, 10 µm
C2001
150 µm id, 15 cm L, 1.9 µm
C18 beads, 1-nozzle, 10 µm
C2002
150 µm id, 20 cm L, 1.9 µm
C18 beads, 1-nozzle, 10 µm
Product Details
Features
- Plug-and-play for DuoESI systems
- Achieve high-sensitivity and high reproducibility for nanoflow LC-MS
- Go beyond the column: PCI introduces novel functions including doping, washing, venting, and more
Performance Highlight
Proteomics of small volumes of biological samples down to single cells has progressed rapidly. However, the sensitivity and reproducibility of ultralow flow LC-MS for proteomics remains a challenge. We developed a silicon-based, plug-and-play, nanoflow MEA chip to directly address this challenge. Our MEA chip monolithically integrates an LC column, an ESI emitter, and a post-column inlet (PCI). Employing silicon-based monolithic fabrication allows for seamless zero dead volume connections necessary for sample-limited proteomic studies. Our chip-based LC columns come with a variety of options that allow them to be used for most mainstream proteomic studies while providing a platform for novel experiments. Herein, we demonstrate that MEA chips achieve performance in small-volume bottom-up proteomics on a par with the top commercial columns while introducing novel functionalities that are not feasible with the current nanoflow LC column technologies. Our MEA chip is “more than a column”. It expands the capabilities of LC-MS and opens the door to new and exciting advancements in proteomics.
Read Application NoteLiterature
To request a MEA Chip user guide, please contact us. Be sure to specify the catalog number.
Webinars
Stanford Webinar: Silicon Microfluidic Chip Platform for Proteomics
Daojing Wang, PhD
Recorded On: May 12, 2022
