DuoESI Source

The DuoESI source is powered by our award-winning multispray M3 emitter and breakthrough monolithic MEA chip, to significantly enhance ionization efficiency and achieve high sensitivity, throughput, and robustness for multiomics analysis.

Its swappable microflow and nanoflow modules deliver two ion sources (nano/micro) in one, reducing sample preparation and SOPs. It is compatible with mass spectrometers from five of the world’s leading mass spec vendors.

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The DuoESI source is powered by our award-winning multispray M3 emitter and breakthrough monolithic MEA chip, to significantly enhance ionization efficiency and achieve high sensitivity, throughput, and robustness for multiomics analysis.

Its swappable microflow and nanoflow modules deliver two ion sources (nano/micro) in one, reducing sample preparation and SOPs. It is compatible with mass spectrometers from five of the world’s leading mass spec vendors.

Request QuoteAsk a Question

Enhanced Workflow

Built for Superior Microflow and Nanoflow LC-MS

Sensitivity

5 - 50x

more sensitive compared to conventional methods.

Robustness

CV ≤ 5%

from 300 plasma injections.

Throughput

< 1 min.

per sample for direct infusion ESI. More than 60 samples per hour.

Product Configurations

Compatible with Agilent, Bruker, Shimadzu, and Thermo Fisher Mass Spectrometers

IS-A01D

for Agilent MS

Compatible with: 6500 Series Q-TOF, 6400 Series QQQ, 6200 Series TOF, and all other Agilent MS

IS-B01D

for Bruker MS

Compatible with: timsTOF series (timsTOF Pro, timsTOF Pro2, timsTOF SCP, timsTOF flex), Compact, impact II, and maxis II QTOF MS, maXisTOF flex MALDI-2 MS (ESI side), solariX and scimaX MRMS; amazon Ion Trap MS

IS-S01D

for Shimadzu Mass Spectrometers

Compatible with: LCMS-9030, LCMS-9050, LCMS-8045, LCMS-8050, LCMS-8060, LCMS-8060NX, and other Shimadzu LCMS

IS-T01D

for Thermo Fisher MS (New Generation)

Compatible with: Orbitrap Exploris (120, 240, 480), Orbitrap Tribrid Series (Fusion, Lumos, ID-X, Eclipse, Ascend), TSQ Series II (Endura, Quantiva, Altis, Quantis, Fortis)

IS-T02D

for Thermo Fisher MS (Legacy)

Compatible with: Q Exactive Series (QE Focus, QE, QE Plus, QE HF, QE HFX, QE UHMR), Exactive Series (Exactive Plus, Exactive Plus EMR), Orbitrap Elite LTQ Series (LTQ XL, LTQ Orbitrap XL, Velos Pro), LCQ Fleet TSQ Series (Quantum, Vantage)

Product Details

  • Features
  • Specifications
  • Literature

    • Features

    • The first interchangeable microflow and nanoflow ion source by a simple swap
    • Compatible with all mass spectrometers from Thermo, Bruker, and Agilent
    • Plug-and-play platform for nanoflow and microflow MEA chips
    • Plug-and-play platform for M3 emitters
    • Receive two ion sources for the price of one

    Specifications

    ParameterSpecifications
    Ionization Mode

    Atmospheric pressure electrospray ionization (ESI), both positive and negative mode.

    ESI Probe

    Newomics M3 Emitter (refer to M3 Emitter and MEA Chip specification)

    Open or Closed System

    Semi-closed source

    Flow Rate

    Nano (20 – 1000 nL/min), for nanoMEA chips
    Micro (1 – 50 µL/min), for M3 emitters and microMEA chips

    Spray Angle

    Fixed angle of 25° for M3 emitters
    0° angle for nanoMEA chips

    Capillary Voltage

    0 – 6 kV

    Spray Current

    0 – 10 µA, max. 40µA

    Sheath Gas Flow Setting

    0 – 30 (arbitrary units)

    N2 Nebulizer Gas Flow Setting

    0 – 60 psi

    Auxiliary Gas Flow Setting

    0 – 20 (arbitrary units, optional)

    Translational Stage

    Linear XY-axis manual stage, ±5 mm travel distance, 30 µm travel accuracy

    Camera

    1.3M pixels, 20x ̶ 90x magnification rate, color CMOS sensor, up to 30 fps frame rate

    Light Source

    Cool white (9000K) 5 mm round LED light, luminous intensity 46400 mcd

    Connection

    Face seal, finger-tight 10-32 threaded fittings including Thermo nanoViper, IDEX MarvelX and MarvelXACT, Waters ZenFit, Phenomenex SecurityLink, VICI Cheminert C360IZR1, and nanoConnect

    Unit Dimension

    Width: 25 cm (9.8 in.)
    Height: 17.5 cm (6.9 in.)
    Depth: 15 cm (5.9 in.)

    Unit Weight

    3 kg (6.6 lbs)

    ModelSpecifications
    Catalog # IS-A01D

    DuoESI Source for Agilent Mass Spectrometers:
    6500 Series Q-TOF, 6400 Series QQQ, 6200 Series TOF, and all other Agilent MS

    Catalog # IS-B01D

    DuoESI Source for Bruker Mass Spectrometers:
    timsTOF series: timsTOF Pro, timsTOF Pro2, timsTOF SCP, timsTOF flex;
    Compact, impact II, and maxis II QTOF MS;
    maXisTOF flex MALDI-2 MS (ESI side);
    solariX and scimaX MRMS;
    amazon Ion Trap MS

    Catalog # IS-S01D

    DuoESI Source for Shimadzu Mass Spectrometers:
    LCMS-9030, LCMS-9050, LCMS-8045, LCMS-8050, LCMS-8060, LCMS-8060NX, and other Shimadzu LCMS

    Catalog # IS-T01D

    DuoESI Source for Thermo Fisher New Generation Mass Spectrometers:
    Orbitrap Exploris (120, 240, 480)
    Orbitrap Tribrid Series (Fusion, Lumos, ID-X, Eclipse, Ascend)
    TSQ Series II (Endura, Quantiva, Altis, Quantis, Fortis)

    Catalog # IS-T02D

    DuoESI Source for Thermo Fisher Legacy Mass Spectrometers:
    Q Exactive Series (QE Focus, QE, QE Plus, QE HF, QE HFX, QE UHMR)
    Exactive Series (Exactive Plus, Exactive Plus EMR)
    Orbitrap Elite LTQ Series (LTQ XL, LTQ Orbitrap XL, Velos Pro)
    LCQ Fleet TSQ Series (Quantum, Vantage)

    Literature