The Unified Multiomics PlatformPowered by "Multispray"

The Unified Multiomics PlatformPowered by "Multispray"

Our UniESI system, powered by the breakthrough multispray technologies of our M3 emitters and MEA chips, is an integrated front-end solution for superior microflow and nanoflow LC-MS. Swappable nanoflow and microflow modules make the system a versatile dual nano/micro ion source for mass spectrometry.

It’s truly one of a kind for proteomics, metabolomics, single-cell omics, and many other emerging mass spectrometry applications.

Our platform is compatible with mass spectrometers from:

Agilent, Bruker, Thermo Fisher, and Shimadzu logos

The NewomicsPlatform







Multispray for Multiomics

Our UniESI Platform

Our UniESI source is the first ion source to offer multiple swappable microflow and nanoflow modules. It is compatible with all mass spectrometers from Thermo, Bruker, Agilent, Shimadzu, and Waters. Key features of the platform include: (1) Plug-and-play compatibility with Newomics M3 emitters and MEA chips; (2) Plug-and-play compatibility with third-party columns and other LCMS consumables. This makes it a universal, unified ion source for low-flow electrospray ionization mass spectrometry.

Learn about Ion Sources

Go Beyond the Column

Our MEA Chip

Our proprietary MEA chip achieves performance in small-volume bottom-up proteomics on par with the top commercial columns. All this while introducing novel functionalities –such as post-column mixing and chemistry– that are not feasible with current nanoflow LC column technologies.

It expands the capabilities of LC-MS and opens the door to new and exciting advancements in multiomics.

Learn about the MEA Chip

Enable New Applications

Our M3 Emitter

close-up of multispray

Our award-winning silicon microfluidic chip, the multinozzle M3 emitter, is our foundational breakthrough. It splits incoming flow into multiple smaller streams to dramatically enhance ionization. Our MEA chip monolithically integrates it with an on-chip LC column, reducing dead volume and simplifying the connection for nanoflow and microflow LC-MS.

It enables new mass spectrometry applications for clinical diagnostics, biomarker discovery, drug development, food and environmental monitoring, forensic analysis, and more.

Learn about the M3 Emitter

Enhanced LC-MS Performance


5 - 50x

more sensitive compared to conventional methods.


CV ≤ 5%

from 300 plasma injections.


< 1 min.

per sample. More than 60 samples per hour.

See How Our M3 Emitters Work


Compared to the conventional single-nozzle emitters, the M3 emitter from Newomics provides 3-5 times higher peptide signals in ESI-MS and more robust and stable spray across the LC gradient. This allows me to use microliter flow rate LC-MS for a large set of biological samples for biomarker discovery, and ensures the reproducible results and similar sensitivity as nanoLC-MS has.

Shujia Dai, Ph.D.

The 8-nozzle emitter showed a 5-10-fold increase in sensitivity for protein therapeutics in human serum compared to the standard LC-MS (HESI source) at the flow rate of 5 μL/min. Preliminary analysis of replicate injections from the same samples showed an excellent CV by the measurement of peak area ratios and no additional carryover.

Ji Ma, Ph.D.
formerly with Amgen

3X improvement in peak intensities was observed for the 8-nozzle emitter in comparison with the ESI sprayer for non-denaturing LC-MS. Moreover, the generally sharper peaks and charge envelope shifted towards higher m/z suggest a more nanospray-like emission and possibly better preservation of the native conformation.

Theresa McLaughlin, Ph.D.

From my tests, the detection of a mix of 10 peptides spiked in plasma extracts, was 5-6X more sensitive (and up to > 10X) with Newomics multi-nozzle emitter than with classical ESI source with a single-nozzle.

Bertrand Rochat, Ph.D.
University of Lausanne

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