Versatile, Sensitive, and Robust Native LC-MS Platform for Intact Mass Analysis and Protein Drugs

February 23, 2021 10:00-11:00am PST / 1:00 - 2:00pm EST

Speaker: Yuetian Yan, Ph.D.
Staff Scientist @ Regeneron Pharmaceuticals

In this webinar, Dr. Yan will describe the development of a versatile, sensitive, and robust nLC−MS platform that can support various nLC−MS applications. The platform can tolerate a wide range of LC flow rates and high salt concentrations, which are critical for accommodating different nLC methods. In addition, a dopant-modified desolvation gas can be readily applied on this platform to achieve online charge-reduction native MS, which improves the characterization of both heterogeneous and labile biomolecules. This platform be routinely applied in protein drug characterization.

Speaker

Yuetian Yan, Ph.D.

Staff Scientist @ Regeneron Pharmaceuticals

Dr. Yan’s research focuses on developing native LC/MS based methods for therapeutic protein characterization for supporting mAb drug development and regulatory filings.

Speaker and Host

Na Pi Parra, Ph.D.

Senior Director of Marketing and Customer Support @ Newomics

Dr. Na Pi Parra uses her years of experience, as the former US Western Regional Manager of Life Science Mass Spectrometry at Bruker, to ask the relevant questions you want answered.

**There will also be audience Q&A at the end of the segment

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