MnESI-MS Platform for Sensitive Analysis of Oligonucleotides

Application Note

High-flow ion-pairing reversed-phase LC-MS has become the new method of choice for oligonucleotide analysis. However, the current LC-MS practice typically has a low sensitivity for negative ionization mode and high contamination to the MS. Now with the Newomics MnESI-MS platform, it’s possible to achieve more than 30-fold sensitivity gain and lower contamination due to less ion-pairing reagent entering the MS.

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